Animal testing and research: guidance for the regulated community (2022)

Animals in Science Regulation Unit (ASRU) guidance and regulatory advice

You can read ASRU guidance that explains how the act is administered and enforced including detailed regulatory advice for licence holders

From 5 July 2021, ASRU now provides regulatory delivery through 2 teams covering different areas each of which has a dedicated inbox. Read the Bridging ways of working guidance for advice.

Apply for licences

Three licences are required by the Animals (Scientific Procedures) Act 1986 (ASPA) before testing on animals is allowed. The 3 licences needed are:

  • personal licence for each person carrying out procedures on animals
  • project licence for the programme of work
  • establishment licence for the place at which the work is carried out

You should use the Animals in Science Procedures e-Licensing (ASPeL) system for all personal and project licence applications.

Contact your establishment’s Home Office liaison contact/administrator to start your application online.

If you are from an establishment that is not yet licensed, email ASPELTechnicalQueries@homeoffice.gov.uk.

Any named person responsible for animal welfare on the establishment licence will need to complete a conflict of interest declaration form.

Before applying, please read the standard conditions for personal licences, project licences and establishment licences.

You can also read guidance on:

  • improving your project licence application
  • data protection impact assessment for the Animals in Science Procedures e-Licensing system

Project Licence Standard Condition 18 notification

All project licences are subject to a set of standard conditions. Standard Condition 18 requires that the project licence holder (PPLh) notifies the Secretary of State as soon as possible if constraints on the severity limits, or observance of other controls described in the licence, have been breached or are likely to have been breached.

You can read the Advice note - Project Licence Standard Condition 18 Notification (PDF, 544 KB, 22 pages), and use the form Project Licence Standard Condition 18 Notification form (ODT, 31.8 KB) to make reports.

Annual returns on the use of protected animals

Statistics are collected annually in the UK to meet the requirements of the Animals (Scientific Procedures) Act 1986 to collect and publish statistical information on the use of protected animals in regulated procedures.

If you are a project licence holder, read the guidance on the annual returns process.

Newsletters

The Animals in Science Regulation Unit newsletters are sent out by the ASRU. If you have any questions about their content, email asrubusiness@homeoffice.gov.uk.

Register for updates

Sign up for email updates on this topic.

Use ASRULicensing@homeoffice.gov.uk for:

  • specific queries relating to an individual licence application
  • evidence to support an exemption from mandatory training
  • requests to re-home animals where not already authorised
  • advice on interpretation of licence authorities
  • guidance on becoming an establishment
  • advice on whether work needs to be regulated
  • advice on applying for licences
  • guidance on how we will assess applications
  • information to support a PEL application or amendment notification of AWERB dates
  • AWERB terms of reference

Use ASRUEnforcement@homeoffice.gov.uk for:

  • reports of potential non-compliance
  • reports required by a licence condition or as a result of enforcement action
  • advice on whether a non-compliance may have occurred
  • contact during a non-compliance investigation
  • POLE notifications

Use ASRUStandardCondition18@homeoffice.gov.uk for:

  • requests to keep animals alive
  • Standard Condition 18 reports

Use ASRUAudit@homeoffice.gov.uk for:

  • audit related queries

Use ASPELTechnicalQueries@homeoffice.gov.uk for:

  • technical advice on the use of ASPeL

Use ASRUOperationalRelationshipManagement@homeoffice.gov.uk for:

Published 26 March 2013
Last updated 28 June 2022 +show all updates

  1. Added the following documents: standard genetically altered rodents protocols, standard genetically altered zebrafish protocols, guidance on the use of standard genetically altered animals.

  2. Updated email addresses under 'Apply for licence' and 'Contact information and forms'. Updated 'Register for updates' form link.

  3. Updated 'Bridging ways of working guidance' PDF.

  4. Added link to "Process and standards for establishment full system audits" in "Animals in Science Regulation Unit (ASRU) Guidance and regulatory advice" section.

  5. 'Contact us' section updated to include (word) enquiry form.

  6. Bridging ways of working guidance added.

  7. Added link to non-technical summaries granted in 2020.

  8. Added link to non-technical summaries granted in 2019.

  9. Added a link to the 2019 statistics on scientific procedures on living animals.

  10. Updated to change link from 2017 annual report to 2018 annual report.

  11. Added a link to non-technical summaries granted in 2018.

  12. Added link to non-technical summaries granted in 2017.

  13. Added a link to the 2018 statistics on scientific procedures on living animals.

  14. Updated to add 2017 annual report

  15. Added a new section called, Project Licence Standard Condition 18 notification.

  16. Published 2016 annual report

  17. Updated guidance.

  18. Added 2016 scientific procedures on living animals report.

  19. Newsletter published.

  20. Latest newsletters published.

  21. 2017 annual return form and guidance published.

  22. Newsletter added

  23. Updated application guidance published

  24. Updated scientific procedures on living animals link to the 2015 publication.

  25. Information about working with animals taken from the wild included.

  26. Guidance on standard breeding protocols for genetically modified animals

  27. Added non-technical summaries for projects granted in 2014.

  28. Guidance on the use of human material in animals published.

  29. Form for 2016 annual returns of procedures published.

  30. Updated instructions for the annual returns procedures 2015 published.

  31. New animal use data return procedures form published.

  32. Removed form for outstanding returns from 2014.

  33. Three advice notes published.

  34. Updated guidance.

  35. Updated overview summary.

  36. Updated version.

  37. Explanatory memorandum to the code of practice for the care and accommodation of animals published.

  38. Code of practice for the care and accommodation of animals (short guide) published.

  39. Added links to 'Statistics of scientific procedures on living animals, Great Britain 2012' and 'Animals in Science Regulation Unit Annual Report 2012'.

  40. Link to section 24 online consultation added.

  41. Guidance on Animals (Scientific Procedures) Act 1986 (ASPA) has been published.

  42. Guidance on the naming of products and substances in project licences for batch quality control and regulatory toxicology added.

  43. Volume 1 of the non-technical summaries from licences granted during 2013 released.

  44. Annual returns instructions, notes and form updated

  45. First published.

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