Uncovering a Rare Side Effect: Esotropia Induced by Short-Term Atropine Treatment (2025)

Myopia, a common visual impairment, is on the rise, especially among children. While low-dose atropine (LDA) has shown promise in managing progressive myopia, it's not without its rare side effects. In this article, we delve into a unique case of esotropia induced by short-term LDA treatment, highlighting the importance of understanding potential complications.

A Rare Complication Unveiled

An 8-year-old boy presented with gradually worsening distance vision. Despite a new prescription, he experienced occasional double vision. Further examination revealed comitant intermittent esotropia, a rare condition.

But here's where it gets controversial: the patient had no history of strabismus surgery or increasing atropine dosage.

Unraveling the Mystery

Several factors could have contributed to the esotropia. High myopia, excessive convergence demand, and atropine-induced accommodative lag likely played a role. Additionally, the patient's short working distance added to the binocular stress.

Atropine, a cycloplegic agent, interferes with accommodation. However, LDA may only induce partial cycloplegia, allowing residual accommodation. This retained effort can trigger excessive convergence, potentially leading to esodeviation.

An Effective Alternative

Multifocal soft contact lenses emerged as a viable solution. By creating peripheral myopic defocus, these lenses slow axial elongation while preserving normal accommodation. In this case, the lenses effectively restored fusion and reduced esodeviation, showcasing their potential for children with binocular dysfunction.

And this is the part most people miss: the anticholinergic effect of atropine can enhance central accommodative effort, potentially contributing to esotropia. Similar cases have been documented with systemic anticholinergics, further emphasizing the need for caution.

Conclusion and Call for Action

While LDA is generally safe and effective, it can trigger esotropia and binocular disruptions. If esodeviation occurs, discontinuing atropine and exploring alternative myopia control methods is crucial. Close monitoring of binocular vision parameters is essential to strike a balance between effective myopia control and preserving binocular function.

Further research is warranted to understand the impact of LDA on accommodative convergence in high myopia cases and evaluate the effectiveness of alternative approaches.

Have you encountered similar cases? Share your thoughts and experiences in the comments. Let's spark a discussion and enhance our understanding of this complex issue.

Uncovering a Rare Side Effect: Esotropia Induced by Short-Term Atropine Treatment (2025)
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